QR016, Rb

Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human PAX8
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Ovarian carcinoma, thyroid carcinomas
Synonyme:Paired Box Gene 8, paired box homeotic gene 8, Paired box protein Pax 8, Paired Domain Gene 8, PAX 8,PAX-8.
Verfügbar in folgenden Ländern:worldwide

PAX8 is a member of the PAX family (Paired Box) of transcription factors. It is vital for organogenesis during the embryonic development of the kidneys, Müller organs and thyroid. Due to the restrictive expression in normal tissues, PAX8 is a sensitive and specific marker for primary tumors as well as for metastatic tumors from the above-mentioned organs and tissues. PAX8 is expressed in renal cell carcinomas of clear cell, papillary and chromophobic subtypes. It is also found in endometrioid carcinomas, serous carcinomas and thyroid carcinomas.


[1] Bellevicine C, Iaccarino A, Malapelle U et al. (2013): PAX8 is expressed in anaplastic thyroid carcinoma diagnosed by fine-needle aspiration: a study of three cases with histological correlates. Eur J Endocrinol. 169(3):307-11.
[2] Ozcan A, Shen SS, Hamilton C et al. (2011): PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study. Mod Pathol. 24(6):751-64.
[3] Tong GX, Yu WM, Beaubier NT et al. (2009): Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Mod Pathol. 22(9):1218-27.
[4] Plachov D, Chowdhury K, Walther C et al. (1990): Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development. 110(2):643-51.
[5] Poleev A, Fickenscher H, Mundlos S et al. (1992): PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. Development. 116(3):611-23.
[6] Wang Y, Wang Y, Li J et al. (2031): PAX8: a sensitive and specific marker to identify cancer cells of ovarian origin for patients prior to neoadjuvant chemotherapy. J Hematol Oncol. 6:60.