QR011, Rb

Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Colon carcinoma, colon mucosa
Synonyme:DNA mismatch repair protein MSH6, G/T mismatch binding protein, GTBP, GTMBP, HNPCC 5, HNPCC5, HSAP, MSH 6, mutS (E. coli) homolog 6, MutS alpha 160 kDa subunit, mutS homolog 6, p160, Sperm associated protein.
Verfügbar in folgenden Ländern:worldwide

MSH6, also known as MutS homologue 6, is a key protein in DNA mismatch repair system. Mutations in MSH6 gene may lead to microsatellite instability (MSI) caused by accumulation of errors in DNA replication during cell proliferation. MSI is associated with Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome), which is characterized by the development of colorectal cancer, endometrial cancer and various other tumors at early age.
Antibody MSH6 is useful in detection of MSI, especially in a panel with MSH2 (-M004-), PMS2 (-P005-) and MLH1 (-M001-).


[1] Edelbrock MA, Kaliyaperumal S and Williams KJ (2013): Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities. Mutat Res. 743-744:53-66.
[2] Vasen HF, Hendriks Y, de Jong AE et al. (2004): Identification of HNPCC by molecular analysis of colorectal and endometrial tumors. Dis Markers. 20(4- 5):207-13.
[3] Kawakami H, Zaanan A and Sinicrope FA (2015): Microsatellite instability testing and its role in the management of colorectal cancer. Curr Treat Options Oncol. 16(7):30.