QR010, Rb

Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Synonyme:MSH-2, FCC1, COCA1, HNPCC, LCFS2, HNPCC1, BAT26, COCA 1, COCA1, DNA mismatch repair protein Msh2, FCC 1, FCC1, hMSH2, HNPCC 1, HNPCC, HNPCC1, LCFS2, MSH 2, Msh2, MSH2_HUMAN, MutS homolog 2, MutS homolog 2 colon cancer nonpolyposis type 1, MutS protein homolog 2.
Verfügbar in folgenden Ländern:worldwide

MSH2, also known as MutS homologue 2, is a key protein in DNA mismatch repair system. Mutations in MSH2 gene may lead to microsatellite instability (MSI) caused by accumulation of errors in DNA replication during cell proliferation. MSI is associated with Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome), which is characterized by the development of colorectal cancer, endometrial cancer and various other tumors at early age.
Antibody MSH2 is useful in detection of MSI, especially in a panel with MSH6 (-M005-), PMS2 (-P005-) and MLH1 (-M001-).


[1] Edelbrock MA, Kaliyaperumal S and Williams KJ (2013): Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities. Mutat Res. 743-744:53-66.
[2] Vasen HF, Hendriks Y, de Jong AE et al. (2004): Identification of HNPCC by molecular analysis of colorectal and endometrial tumors. Dis Markers. 20(4- 5):207-13.
[3] Kawakami H, Zaanan A and Sinicrope FA (2015): Microsatellite instability testing and its role in the management of colorectal cancer. Curr Treat Options Oncol. 16(7):30.