IRTA1

QM005, Ms

Artikelnummer:I002-H
Menge:
Technische Daten
Change(s) made:Complete revision
Status:In Vitro Diagnostic Use (IVD)
Spezies:Mouse
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human IRTA1
Vorbehandlung:ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Membranous
Kontrolle:Tonsil, marginal zone lymphoma
Synonyme:CD307d, Fc receptor homolog 4, Fc receptor like 4, Fc receptor like protein 4, Fc receptor-like protein 4, FcR like protein 4, FcR-like protein 4, FcRH4, FcRL4, FCRL4_HUMAN, hIFGP2, IFGP family protein 2, IGFP2, Immune receptor translocation associated protein 1, Immune receptor translocation-associated protein 1, Immunoglobulin superfamily receptor translocation associated 1, Immunoglobulin superfamily receptor translocation associated gene 1, IRTA1
Verfügbar in folgenden Ländern:worldwide
Beschreibung

IRTA1 (Immunoglobulin superfamily Receptor Translocation-Associated 1), otherwise known as Fc-receptor-like 4 (FCRL4) or CD307 d, is a structural member of a family of immunoglobulin-like proteins that mediate the immune response of B-cells. In normal lymphoid tissues IRTA1 is expressed in benign monocytoid B-cells, in some marginal zone cells, and in intraepithelial B-cells. In lymphomas it is expressed by tumor cells involved in lympho-epithelial lesions. In marginal lymphomas, marginal zone B-cells selectively express IRTA1, both in non-neoplastic lymphoid tissues and in malignant lymphomas. This provides the opportunity to accurately diagnose marginal lymphomas with a commercially available antibody. The new anti-IRTA1 antibody secreted from the quartett clone QM005 has the same reactivity and specificity as the anti-IRTA1 antibody produced from the clone MUM2. This was determined through analyzing a large number of biopsies with nodal and extranodal marginalzone lymphomas as well as non-marginalzone lymphomas. As a result, a suitable anti-IRTA1 antibody is now available for the detection of marginal zone lymphoma in lymph nodes and extranodal locations.

Literatur

[1] Ikeda, Jun-ichiro, et al. (2017) Human pathology 59:70-79
[2] Falini, Brunangelo, et al. (2012) Histopathology 61.5:930-941
[3] Wangm Zhen, and James R. Cook (2019) American journal of clinical pathology 151.3: 337-343

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