Her2/neu

QR003

Artikelnummer:H001-H
Menge:
Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human HER2/ErbB2
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Membranous
Kontrolle:Breast carcinoma
Change(s) made:Complete revision
Synonyme:C-erbB-2, CerbB2, c erb B2, c erb B2/neu protein, C erbB 2, C-erbB2, HER-2, CD340, cneu, Erb B2, erbb2, Erythroblastosis Virus, HER 2, HER 2/neu, HER2, Her2/neu, Herstatin, MLN 19, MLN19, NEU, NEU proto oncogene, Neuro Glioblastoma Derived Oncogene Homolog, Neuroblastoma/glioblastoma derived oncogene homolog, NGL, p185 ErbB2, p185erbB2, Receptor Protein Tyrosine Kinase ErbB2 Precursor, Receptor tyrosine protein kinase erbB 2, TKR1, Tyrosine kinase type cell surface receptor HER2, v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian), verbb2, v-erb-b2 erythroblastic leukemia viral oncogene-like 2, Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog, CerbB2, c erb B2, C erbB 2, C-erbB2, CD340, CD340 antigen, Cerb B2/neu protein, Erb B2, erbb2, ERBB2_HUMAN, HER 2, HER 2/neu, HER2, Her2/neu, Herstatin, Metastatic lymph node gene 19 protein, MLN 19, MLN19, NEU, NEU Proto Oncogene, Neuro Glioblastoma Derived Oncogene Homolog, Neuroblastoma/glioblastoma derived oncogene homolog, NGL, p185 ErbB2, p185erbB2, Proto-oncogene c-ErbB-2, Proto-oncogene Neu, Receptor Protein Tyrosine Kinase ErbB2 Precursor, Receptor tyrosine protein kinase erbB 2, Receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase type cell surface receptor HER2, Tyrosine kinase-type cell surface receptor HER2, v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian), Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian).
Verfügbar in folgenden Ländern:worldwide
Beschreibung

Her2/Neu is a member of human epidermal growth factor family and encodes for a receptor tyrosine kinase involved in signal paths of growth factors. Overexpression of Her2/Neu gene is associated with development of various carcinomas including breast, ovary, colon, prostate, bladder and lung. Her2/Neu plays an important role in diagnosis and therapy of breast cancer as it is overexpressed in 15 Ð 30 % of all cases, which has been shown to be an indicator for poor prognosis with more aggressive progression of disease and decreased overall survival.

Literatur

[1] M_nard S, Pupa SM, Campiglio M and Tagliabue E (2003): Biologic and therapeutic role of HER2 in cancer. Oncogene. 22: 6570-6578.
[2] Ellis CM, Dyson MJ, Stephenson TJ and Matlby EL (2005): HER2 amplification status in breast cancer: a comparison between immunohistochemical staining and fluorescence in situ hybridisation using manual and automated quantitative image analysis scoring techniques. J Clin Pathol. 58: 710-714.
[3] Muthuswamy SK, Gilman M and Brugge JS (1999): Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Mol Cell Biol. 19(10): 6845-6857.
[4] Klapper LN, Waterman H, Sela M and Yarden Y (2000): Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2. Cancer Res. 60(13): 3384-3388.
[5] Ricardo SA, Milanezi F, Carvalho ST et al. (2007): HER2 evaluation using the novel rabbit monoclonal antibody SP3 and CISH in tissue microarrays of invasive breast carcinomas. J Clin Pathol. 60(9):1001-5.
[6] Hudziak RM, Schlessinger J and Ullrich A (1987): Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc Natl Acad Sci U S A. 84(20):7159-63.
[7] Kokai Y, Cohen JA, Drebin JA and Greene MI (1987): Stage- and tissue-specific expression of the neu oncogene in rat development. Proc Natl Acad Sci U S A. 84(23):8498-501.

Kontakt