QR018, Rb

Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human GATA-3
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Breast carcinoma, urothelial carcinoma
Change(s) made:Complete revision
Synonyme:GATA 3, GATA3, GATA binding factor 3, GATA binding protein 3, HDR, MGC2346, MGC5199, MGC5445, Trans acting T cell specific transcription factor GATA 3.
Verfügbar in folgenden Ländern:worldwide

GATA3, also known as GATA binding 3, is a zinc finger protein regulating as transcription factor the development of various tissues and cell types, including early T cell development and development of mammary gland. Expression is found in hematopoetic tissues, e.g. T cells, and non-hematopoetic tissues, such as kidney, central nervous system, skin and mammary gland. Decreased expression of GATA3 is associated with poor prognosis in luminal breast cancer. Furthermore, GATA3 may be helpful in detection of urothelial carcinoma.


[1] Chou J, Provot S and Werb Z (2010): GATA3 in development and cancer differentiation: cells GATA have it! J Cell Physiol. 222(1):42-9.
[2] Takaku M, Grimm SA and Wade PA (2015): GATA3 in Breast Cancer: Tumor Suppressor or Oncogene? Gene Expr. 16(4):163-8.
[3] Chang A, Amin A, Gabrielson E et al. (2012): Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. Am J Surg Pathol. 36(10):1472-6.