Estrogen receptor

QR013

Artikelnummer:E001-H
Menge:
Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Estrogen Receptor
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Nuclear
Kontrolle:Breast carcinoma, breast
Change(s) made:Complete revision
Synonyme:ER alpha, ER, ESR 1, ESRA, Estradiol receptor, Estrogen nuclear receptor alpha, Major ORF, NR3A1, Nuclear receptor subfamily 3 group A member 1
Verfügbar in folgenden Ländern:worldwide
Beschreibung

ER is a nuclear hormone receptor that activates transcription of various genes, especially in reproductive tissues, regulated by its ligand estrogen. The antibody stains nuclei of cells with high levels of ER, e.g. epithelial cells and carcinoma of breast, uterus, ovary, and prostate. ER is expressed in approximately 75 % of all breast cancer cases. It is reported that patients with ERpositive tumors have better prognosis than patients with ER-negative tumors. The stated antibody may be helpful in detection of breast carcinoma.

Literatur

[1] Lim E, Tarulli G, Portman N, et al. (2016): Pushing estrogen receptor around in breast cancer. Endocr Relat Cancer. 23(12): T227-T241.
[2] Farzaneh S, & Zarghi A (2016): Estrogen Receptor Ligands: A Review (2013-2015). Sci Pharm. 84(3):409- 427.
[3] Gown AM (2008): Current issues in ER and HER2 testing by IHC in breast cancer. Mod Pathol. 21 Suppl 2:S8-S15.

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