Technische Daten
Status: | In Vitro Diagnostic Use (IVD) | Spezies: | Rabbit | Ig Unterklasse: | IgG | Immunogen: | Synthetic peptide of human Cyclin D1 | Vorbehandlung: | ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392) | Zelluläre Lokalisation: | Nuclear | Kontrolle: | Breast carcinomas, mantle cell lymphoma | Change(s) made: | Complete revision | Synonyme: | Cyclin D1, CyclinD1, Cyclin-D1, B cell ccl/lymphoma 1, B cell leukemia 1, B-cell CLL/lymphoma 1, B-cell leukemia 1, B-cell lymphoma 1 protein, BCL-1, BCL1, BCL1 oncogene, CCND 1, CCND1, CCND1 protein, CCND1/FSTL3 fusion gene, included, CCND1/IGHG1 fusion gene, CCND1/IGHG1 fusion gene, included, CCND1/IGLC1 fusion gene, included, CCND1/PTH fusion gene, included, Parathyroid adenomatosis 1, PRAD1. | Verfügbar in folgenden Ländern: | worldwide |
Beschreibung
Cyclin D1 plays an important role in control of cell cycle and cell proliferation by regulating cyclin-dependent kinases. Cyclin D1 is a proto-oncogen. Overexpression and nuclear accumulation is associated with various cancers including breast, colon and prostate cancer, melanoma and lymphoma. Cyclin D1 may be used to differentiate mantle cell lymphoma from other B cell lymphoma.
Literatur
[1] FustŽ NP, Castelblanco E, Felip I et al. (2016): Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer. Oncotarget. 7(19): 26979-26991.
[2] Pathak P, Li Y, Gray BA et al. (2017): Synchronous Occurrence of Chronic Myeloid Leukemia and Mantle Cell Lymphoma. Case Rep Hematol. 2017: 7815095.
[3] Nœ–ez KG, Gonzalez-Rosario J, Thevenot PT and Cohen AJ (2017): Cyclin D1 in the Liver: Role of Noncanonical Signaling in Liver Steatosis and Hormone Regulation. Ochsner J. 17(1): 56-65.
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