QR004, Rb

Technische Daten
Status:In Vitro Diagnostic Use (IVD)
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human CD3 epsilon
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Zelluläre Lokalisation:Membranous
Change(s) made:Complete revision
Synonyme:T-cell surface glycoprotein CD3 epsilon chain, IMD18, T3E, TCRE, CD3e molecule
Verfügbar in folgenden Ländern:worldwide

CD3 is a protein complex that is composed of five chains (gamma, delta, epsilon, zeta, eta) which associate with the T-cell receptor (TCR). CD3e, also known as T-cell surface glycoprotein CD3 epsilon chain, is a membrane protein that plays a role in TCR-CD3 complex assembly and signal transduction regulating T-cell proliferation, apoptosis and thymocyte development. Some signal transducing molecules recruited by CD3e are oncogenic leading to disturbance in CD3e signaling. Overexpression of CD3e is associated with high incidence of T-cell lymphomas whereas no lymphomas were detected at low or absent CD3e expression. Defects in CD3e are linked to immunodeficiency.
CD3e (QR004) may be helpful in detection of T-cells and T-cell derived malignancies including multiple myeloma, acute myeloid leukemia or chronic lymphocytic leukemia.
CD3e in combination with CD56 (-CD436-) is a characterization marker to distinguish NK cells from other immune cells. The NK-cell phenotypic expression of CD3_ and CD56 is also a very useful marker for Extranodal NK/T-cell lymphoma (ENKTCL), a highly aggressive mature NK/T-cell neoplasm.


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