Technische Daten
Kontrolle:Breast, GIST, skin, testes
Zelluläre Lokalisation:Cytoplasmic, membranous
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Immunogen:Synthetic peptide of human CD11
Ig Unterklasse:IgG
Status:In Vitro Diagnostic Use (IVD)
Change(s) made:Complete revision
Synonyme:C Kit, CD 117, CD117, CD117 antigen, KIT, Mast/stem cell growth factor receptor, PBT, Proto oncogene tyrosine protein kinase Kit, Tyrosine-protein kinase Kit, SCF Receptor, SCFR, Stem cell factor receptor, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog, Bs, c-KIT, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W.
Verfügbar in folgenden Ländern:worldwide

CD117, also known as c-Kit, encodes a receptor tyrosine kinase that is activated by its ligand stemm cell factor and plays an important role in vital functions, such as homeostasis and melanogenesis. CD117 is a proto-oncogene. Mutations and overexpression are associated with several cancer types, including gastrointestinal stromal tumors (GIST), mast cell diseases, acute myeloid leukemia (AML), small cell lung carcinoma (SCLC), and Ewing's sarcoma. Expression is found in a variety of normal and abnormal cells, such as hematopoetic stem cells, melanocytes, mast cells, germ cells, and basal cells of skin.


[1] Abbaspour Babaei M, Kamalidehghan B, Saleem M et al. (2016): Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells. Drug Des Devel Ther. 10:2443-59.
[2] Zhao F, Chen Y, Wu Q et al. (2014): Prognostic value of CD117 in cancer: a meta-analysis. Int J Clin Exp Pathol. 7(3):1012-21.