QR017, Rb

Technische Daten
Kontrolle:Anaplastic large cell lymphoma
Zelluläre Lokalisation:Cytoplasmic, nuclear
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Ig Unterklasse:IgG
Status:In Vitro Diagnostic Use (IVD)
Change(s) made:Complete revision
Synonyme:ALK tyrosine kinase receptor, CD246, Anaplastic lymphoma kinase
Verfügbar in folgenden Ländern:worldwide

Anaplastic lymphoma kinase (ALK) belongs to the insulin receptor superfamily. It is a transmembrane receptor protein-tyrosine kinase and it can create a fusion protein with the nuclear protein gene nucleiphosmin (NPM). ALK can be active in cancer through multiple mechanisms. The protein expression by tumor cells is an independent prognostic factor that predicts a favorable outcome. ALK staining is positive in about 60% of anaplastic large cell lymphoma (ALCL). Various solid tumors, such as nonsmall cell lung carcinoma (NSCLC) and brain cancers were also found to aberrantly express the protein.


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[2] Gascoyne RD, Aoun P, Wu D et al. (1999) Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. Blood. 1999. 93(11):3913-21
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