Anaplastic lymphoma kinase/ALK

Rb, 0.5 ml Conc.

Artikelnummer:1-AN007-05
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human NPM-ALK fusion protein
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic, nuclear
Kontrolle:ALK+ anaplastic large cell lymphoma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:ALK tyrosine kinase receptor, ALK tyrosine kinase receptor precursor, ALK/EML4 fusion gene, included, ALK/NPM1 fusion gene, included, anaplastic lymphoma kinase (Ki-1), Anaplastic lymphoma kinase, Anaplastic lymphoma kinase Ki 1, Anaplastic lymphoma kinase Ki1, Anaplastic lymphoma kinase p80, CD 246, CD246, CD246 antigen,EC 2.7.10.1, Ki 1, Ki1, NBLST3, Tcrz, TFG/ALK.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Anaplastic lymphoma kinase (ALK) belongs to the insulin receptor superfamily. It is a transmembrane receptor protein-tyrosine kinase and it can create a fusion protein with the nuclear protein gene nucleiphosmin (NPM). ALK can be active in cancer through multiple mechanisms. The protein expression by tumor cells is an independent prognostic factor that predicts a favorable outcome. ALK staining is positive in about 60% of anaplastic large cell lymphoma (ALCL). Various solid tumors, such as non-small cell lung carcinoma (NSCLC) and brain cancers were also found to aberrantly express the protein.

Literatur

[1] Cessna MH, Zhou H, Sanger WG et al. (2002) Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases. Mod Pathol. 15(9):931-8.
[2] Gascoyne RD, Aoun P, Wu D et al. (1999) Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. Blood. 1999. 93(11):3913-21
[3] Duyster J, Bai RY, Morris SW (2001) Translocations involving anaplastic lymphoma kinase (ALK). Oncogene. 2001. 20(40):5623-37.
[4] Li S (2009) Anaplastic lymphoma kinase-positive large B-cell lymphoma: a distinct clinicopathological entity. Int J Clin Exp Pathol. 2(6):508-18.
[5] Morgan EA and Nascimento AF (2012) Anaplastic lymphoma kinase-positive large B-cell lymphoma: an underrecognized aggressive lymphoma. Adv Hematol. 2012:529572.
[6] Sukov WR, Cheville JC, Carlson AW et al (2007) Utility of ALK-1 protein expression and ALK rearrangements in distinguishing inflammatory myofibroblastic tumor from malignant spindle cell lesions of the urinary bladder. Mod Pathol. 20(5):592-603.
[7] Pulford K, Lamant L, Morris SW et al (1997) Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1. Blood. 89(4):1394-404.

Kontakt