Alpha methylacyl CoA Racemase/AMACR

13H4Rb, 1 ml RTU

Artikelnummer:2-AL052-07
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:13H4
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Alpha-Methylacyl-CoA Racemase
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Prostate adenocarcinoma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:p504s, AMACR
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

AMACR, also known as P504S, is an enzyme that is involved in bile acid biosynthesis and oxidation of branched-chain fatty acids. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia and prostate adenocarcinoma, and at low or undetectable levels in glandular epithelial cells of normal and benign hyperplastic prostates.

Literatur

[1] Jiang Z, Fanger GR, Woda BA et al. (2003): Expression of alpha-methylacyl-CoA racemase (P504s) in various malignant neoplasms and normal tissues: astudy of 761 cases. Hum Pathol. 34(8):792-6.
[2] Jiang Z, Woda BA, Rock KL et al. (2001): P504S: a new molecular marker for the detection of prostate carcinoma. Am J Surg Pathol. 25(11):1397-404.
[3] Varma M, Jasani B (2005): Diagnostic utility of immunohistochemistry in morphologically difficult prostate cancer: review of current literature. Histopathology. 47(1):1-16.
[4] Gologan A, Bastacky S, McHale T et al. (2005): Ageassociated changes in alpha-methyl CoA racemase (AMACR) expression in nonneoplastic prostatic tissues. Am J Surg Pathol. 29(11):1435-41.
[5] Koseoglu E, Tuncel A, Balci M et al. (2018): Netrin 1 and Alpha-Methyl Acylcoenzim-A Racemase in diagnosis of prostate cancer. Colomb Med (Cali). 49(2):164-168.
[6] Kuroda N (2014): Application of combined immunohistochemical panel of AMACR(P504S)/p63 cocktail, cytokeratin 5 and D2-40 to atypical glands in prostatic needle biopsy. Malays J Pathol. 36(3):169-73.
[7] Luo J, Zha S, Gage WR et al. (2002): Alphamethylacyl- CoA racemase: a new molecular marker for prostate cancer. Cancer Res. 62(8):2220-6.

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