Activator of S phase kinase/DBF4A

Rb, 3 ml RTU

Artikelnummer:2-AC052-10
Menge:
Technische Daten
Reaktivität AK:Human, Mouse, Rat, please ask for further reactivities.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human DBF4A
Anwendung AK:IHC(p*) *reported as working on paraffin,IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Zelluläre Lokalisation:Nuclear
Synonyme:Activator of S phase kinase, ASK, Chiffon homolog A, DBF4, DBF4 type zinc finger containing protein 1, DBF4-type zinc finger-containing protein 1, DBF4A, DBF4A_HUMAN, Protein DBF4 homolog A, ZDBF1.
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

DBF4 is a regulatory subunit for CDC7 activating its kinase activity thereby playing a central role in DNA replication and cell proliferation. It is required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' regulating the initiation of DNA replication during cell cycle. Expression is found in testis, thymus, and most cancer cells lines.

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