Actin, smooth muscle

1A4, Ms

Technische Daten
Kontrolle:Smooth muscle
Zelluläre Lokalisation:Cytoplasmic
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Immunogen:Actin of smooth muscle
Ig Unterklasse:IgG2a
Status:In Vitro Diagnostic Use (IVD)
Change(s) made:Complete revision
Synonyme:alpha smooth muscle Actin, Actin alpha, ASMA, _ Actin, A-SMA, _ SMA, _-SMA, ASM-A, alpha-SMA, alpha SMA, AAT6, ACTA2, Actin alpha 2 smooth muscle aorta, Actin aortic smooth muscle, ACTSA, ACTVS, Alpha 2 actin, Alpha cardiac actin, Alpha-actin 2, Cell growth inhibiting gene 46 protein, Growth inhibiting gene 46 , ACTA_HUMAN , Actin alpha 2 smooth muscle aorta , Actin aortic smooth muscle , Actin, aortic smooth muscle , Alpha 2 actin , Alpha actin 2 , Alpha cardiac actin , Alpha-actin 2 , Alpha-actin-2 , Cell growth inhibiting gene 46 protein , Cell growth-inhibiting gene 46 protein , Growth inhibiting gene 46 , MYMY5
Verfügbar in folgenden Ländern:worldwide

Cytoplasmic actins belong to the microfilament system of cytoskeletal proteins and expressed in all eukaryotic cells. Actin consits of six isoforms specific for muscle tissue like cardiac muscle or skeletal muscle, and are thought to play a role in the maintenance of contractile activity and other cellular functions. The Alpha-Actin (Smooth Muscle) antibody recognizes only smooth muscle actin and detects smooth muscle cells, myoepithelial cells and myofibroblasts.


[1] Gabbiani G, Ryan GB, Lamelin JP et al. (1973) Human smooth muscle autoantibody. Its identification as antiactin antibody and a study of its binding to "nonmuscular" cells. Am J Pathol. 72(3):473-88.
[2] Gown AM, Vogel AM, Gordon D et al. (1985) A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes. J Cell Biol. 100(3):807- 13.
[3] Vandekerckhove J and Weber K (1981) Actin typing on total cellular extracts: a highly sensitive proteinchemical procedure able to distinguish different actins. Eur J Biochem. 113(3):595-603.
[4] Yuan SM (2015) _-Smooth Muscle Actin and ACTA2 Gene Expressions in Vasculopathies. Braz J Cardiovasc Surg. 30(6):644-9.
[5] Johnson GD, Holborow EJ and Glynn LE (1965) Antibody to smooth muscle in patients with liver disease. Lancet 2:878-879.