AIF1

Rb

Artikelnummer:MI004-H_RUO
Menge:
Technische Daten
Kontrolle:Brain microglia, astrocytomas
Zelluläre Lokalisation:Cytoplasmic
Vorbehandlung:ProTaqs® Antigen Enhancer I (Cat. No. 401602092) or ProTaqs® Antigen Enhancer IV (Cat. No. 401602392)
Immunogen:Synthetic peptide of human AIF1
Ig Unterklasse:IgG
Spezies:Rabbit
Status:Research Use Only (RUO)
Change(s) made:Complete revision
Synonyme:AIF 1, AIF1, AIF1 protein, IBa1, IBa 1, allograft inflammatory factor 1, Allograft inflammatory factor 1 splice variant G, balloon angioplasty responsive transcription, BART 1, G1, G1 putative splice variant of allograft inflamatory factor 1, IBA 1, IBA1, interferon gamma responsive transcript, Ionized calcium binding adapter molecule 1, ionized calcium-binding adapter molecule, IRT 1, IRT1, Microglia response factor, MRF1, Protein G1.
Verfügbar in folgenden Ländern:worldwide
Beschreibung

AIF1 is found in activated macrophages which are found in tissues with inflammation. AIF1 levels in healthy humans have been found to positively correlate with metabolic indicators, such as body mass index, triglycerides, and fasting plasma glucose levels. The possibility of a role for AIF1 in cancer development has been considered. Significantly higher levels of AIF1 expression were found in hepatocarcinoma cell lines and in tissue compared to healthy samples. One option in which AIF-1 may contribute to the development of pathology is involvement in the proliferation and migration of tumor cells. It was also shown that AIF1 promote cell proliferation in the brest cancer cells line. This effect was dependant on time and level of AIF-1 protein.

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