PD-L1 - Format: 1 ml

QR001, Rb, 1 ml Conc.

Technische Daten
Reaktivität AK:Human, others not tested
Format AK:Concentrate
Ig Unterklasse:IgG1
Immunogen:Synthetic peptide of the PD-L1 protein
Anwendung AK:IHC(p),IHC(f),WB
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic, membranous
Kontrolle:PD-L1 transfected HEK cell pellets, non-small cell lung cancer, tonsil
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)

Programmed Death Ligand 1 (PD-L1), also known as CD274 and B7-H1, is a transmembrane protein expressed on the surface of resting T-cells [1-4]. Binding to its receptor PD-1, a T-cell immune checkpoint, T-cell activation is inhibited and autoimmune reaction is stopped [2,5]. Some tumor cells use this mechanism to prevent apoptosis and obtain resistance against CD8+ Tcell mediated cell lysis [2]. PD-L1 (QR1) is suitable to detect sentinel lymph node melanoma, renal cell carcinoma (RCC), non-small cell lung cancer (NSCLC) as well as triple-negative breast cancer (TNBC). The antibody produces membranous and/or cytoplasmic staining.


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