IDH1 R132H - Format: 1 ml

QM002, Ms, 1 ml Conc.

Artikelnummer:C-I001-10
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:QM002
Spezies:Mouse
Ig Unterklasse:IgG1
Immunogen:Synthetic peptide of human IDH1/Isocitrate dehydrogenase
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic, peroxisome
Kontrolle:Oligodendroglioma, diffuse astrocytoma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Synonyme:Cytosolic NADP isocitrate dehydrogenase, Cytosolic NADP-isocitrate dehydrogenase, ICDH, IDCD, IDH, IDHC, Idh1, IDHC_HUMAN, IDP, IDPC, Isocitrate dehydrogenase [NADP] cytoplasmic, Isocitrate dehydrogenase 1 (NADP+) soluble, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD.
Verfügbar in folgenden Ländern:world wide
Status:RUO - IVD validation in progress
Beschreibung

Isocitrate dehydrogenase 1 is a cytoplasmic enzyme that catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming alpha-ketoglutarate and CO2 in a two step reaction. It is expressed in a wide range of species and also in organisms that lack a complete citric acid cycle. The IDH1 R132H point mutation is shown in more than 70 % of gliomas. The antibody QM002 is highly specific in detection of the mutant protein and contributes the differentiation between a glioblastoma and an anaplastic glioma.

Literatur

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