Cytokeratin AE1/AE3

AE1/AE3, Ms, 0.5 ml Conc.

Artikelnummer:1-CY207-05
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:AE1/AE3
Spezies:Mouse
Ig Unterklasse:IgG1/k
Immunogen:Cytokeratin A1/AE3
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Colon, prostate, salivary gland, skin, stomach
Lagerung AK:Aliquot and store at - 20 °C. Do not use after expiration date indicated on the vial.
Synonyme:pan-keratin
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Cytokeratin, AE1/AE3, is a keratin cocktail that detects CK1-8, 10, 14-16 and 19; it is non-reactive with CK17 or CK18. It recognizes epithelial cells of normal and abnormal human tissues. Therefore, it has been used to characterize the source of various neoplasms and to study the distribution of keratin containing cells in epithelia during normal and neoplastic development. This antibody is useful to distinguish epithelial carcinoma from non-epithelial malignancies.

Literatur

[1] Woodcock-Mitchell J, Eichner R, Nelson WG and Sun TT (1982): Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol. 95(2 Pt 1):580-8.
[2] Nelson WG and Sun TT (1983): The 50- and 58- kdalton keratin classes as molecular markers for stratified squamous epithelia: cell culture studies. J Cell Biol. 97(1):244-51.
[3] Nelson WG, Battifora H, Santana H and Sun TT (1984): Specific keratins as molecular markers for neoplasms with a stratified epithelial origin. Cancer Res. 44(4):1600-3.
[4] Eichner R, Bonitz P and Sun TT (1984): Classification of epidermal keratins according to their immunoreactivity, isoelectric point, and mode of expression. J Cell Biol. 98(4):1388-96.

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