Cytokeratin 7

Rb, 6 ml RTU

Artikelnummer:2-CY164-12
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human CK7
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Adenocarcinoma of lung, salivary gland
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Cytokeratin 7 is a type II keratin that is found in most ductal and glandular epithelium of the urinary tract, bile, lung, breast and female genital tract. This antibody reacts with many benign and malignant epithelial lesions, e.g. adenocarcinomas of the ovary, breast and lung. It does not recognize intermediate filament proteins and is absent in colon and prostate cancer as well as squamous carcinomas. It is a useful marker in combination with CK20.

Literatur

[1] Kummar S, Fogarasi M, Canova A et al. (2002): Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma. Br J Cancer. 86(12):1884-7.
[2] Chu P, Wu E and Weiss LM (2000): Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol. 13(9):962-72.

Kontakt