CD20

Rb, 6 ml RTU

Artikelnummer:2-CD088-12
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human CD20 C-terminal
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Membranous
Kontrolle:Tonsil, B cell lymphoma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

CD20 (Cluster of Differentiation 20) is 35/37 kDa non-glycosylated phosphoprotein expressed on the surface of all B-cells. It is involved in B-cell activation, proliferation and differentiation and therefore one of the most important B-cell markers. This antibody reacts with pre-B cells, resting and activated B cells but not with plasma cells. It detects all mature B-cell lymphoma, lymphoblastic lymphoma/leukemia and Hodgkin's lymphoma.

Literatur

[1] Chu PG, Loera S, Huang Q and Weiss LM (2006): Lineage Determination of CD20- B-Cell Neoplasms. An Immunohistochemical Study. Am J Clin Pathol. 126:534- 44.
[2] Selva RL, Violetti SA, Delfino C et al. (2017): A Literature Revision in Primary Cutaneous B-cell Lymphoma. Indian J Dermatol. 62(2):146-57.
[3] Benharroch D, Nalbandyan K and Lazarev I (2015): CD20 Over-Expression in Hodgkin-Reed-Sternberg Cells of Classical Hodgkin Lymphoma: the Neglected Quest. J Cancer. 6(11):1155-9.

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