Vimentin

V9, Ms, 6 ml RTU

Artikelnummer:2-VI006-12
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:V9
Spezies:Mouse
Ig Unterklasse:IgG1/k
Immunogen:Vimentin
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Tonsil, lymp node
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide
Status:RUO
Beschreibung

Vimentin is a 57 kDa intermediate filament protein which forms part of the cytoskeleton of vertebrate cells and is characteristically found in cells of mesenchymal origin. In combination with other antibodies (in panels) it is useful for the subclassification of a given tumor, otherwise it is a limited diagnostic tool. Vimentin can be used to distinguish melanomas from undifferentiated carcinomas and large cell lymphomas. It marks a variety of mesenchymal cells, including melanocytes, lymphocytes, endothelial cells, and firbroblasts and can be used as a tissue process control.

Literatur

[1] Ben-ZeÕev A (1984): Differential control of cytokeratins and vimentin synthesis by cell- cell contact and cell spreading in cultured epithelial cells. J Cell Biol. 99(4): 1424-1433.
[2] Battifora H (1991): Assessment of antigen damage in immunohistochemistry. The vimentin internal control. Am J Clin Pathol. 96(5):669-71.
[3] Goto H, Tanabe K, Manser E et al. (2002): Phosphorylation and reorganization of vimentin by p21- activated kinase (PAK). Genes Cells. 7(2):91-7.
[4] Yamaguchi T, Goto H, Yokoyama T et al. (2005): Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis. JCB. 171 (3): 431.
[5] Kruslin B, Kopjar A, Dimanovski J et al. (1999): Correlation between vimentin expression and morphological features of renal cell carcinoma. Acta Med Croatica.. 53(1):11-4.
[6] Furuse C, Cury PR, de Araœjo NS et al. (2006): Application of two different clones of vimentin to the diagnosis of salivary gland tumors. 14(2):217-9. Appl Immunohistochem Mol Morphol
[7] Goel, NM Rao, V Santhi et al. (2018): Immunohistochemical Characterization of Normal Ovary and Common Epithelial Ovarian Neoplasm with a Monoclonal Antibody to Cytokeratin and Vimentin. Iran J Pathol. 13(1): 23-29.

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