Caudal type homeo box 2/CDX2

Rb, 6 ml RTU

Artikelnummer:2-CA284-12
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human CDX-2
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Nuclear
Kontrolle:Human gastric adenocarcinoma, colon, colon adenocarcinoma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

CDX2 is a caudal-related homeobox transcription factort that is expressed in the nuclei of intestinal epithelium and has a function in proliferation and differentiation of intestinal cells. This antibody detects primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer.

Literatur

[1] Scholl C, Bansal D, Döhner K et al. (2007): The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest. 117(4): 1037-1048.
[2] Liu Q, Teh M, Ito K et al. (2007): CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer. Mod Pathol. 20(12):1286-97.

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