CD99

Rb, 6 ml RTU

Artikelnummer:2-CD293-12
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human CD99 C-terminal
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Membranous
Kontrolle:Ependyma, EwingÕs Sarcoma, pancreas
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

CD99 (Cluster of Differentation 99) is a transmembrane glycoprotein, that is involved in T-cell adhesion, leukocyte migration and differentiation of primitive neuroectodermal cells. It is expressed on all leukocytes but highest on thymocytes. This antibody detects lymphocyte, ovarian granulosa cells, pancreatic islet cells, sertoli cells, CNS ependymal cells and endothelial cells. It is a useful marker for Ewing's sarcoma, sex cord-stromal tumor, endocrine tumor of pancreas and a subset of other
tumors including lymphoblastic lymphoma, breast carcinoma and other malignancies.

Literatur

[1] Gelin C, Aubrit F, Phalipon A et al. (1989) The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product. EMBO J. 8(11): 3253-3259.
[2] Fellinger EJ, Garin-Chesa P, Triche TJ A et al. (1991) Immunohistochemical analysis of Ewing's sarcoma cell surface antigen p30/32MIC2. Am J Pathol. 139(2): 317- 325.
[3] Lee EJ, Lee HG, Park SH et al. (2003) CD99 type II is a determining factor for the differentiation of primitive neuroectodermal cells. Exp Mol Med. 35(5):438-47.

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