Actin, smooth muscle

1A4, Ms, 6 ml RTU

Artikelnummer:2-AC039-12
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:1A4
Spezies:Mouse
Ig Unterklasse:IgG/k
Immunogen:Actin of smooth muscle
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Smooth muscle
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Actin is a major component of the cytoskeleton. This antibody reacts with actin of myofibroblasts and myoepithelial cells, no cross-reaction with actin of cardiac or skeletal muscle. Paired with Actin Muscle Specific, a discrimination between leiomyosarcoma and rhybdomyosarcoma is possible.

Literatur

[1] Gabbiani G, Ryan GB, Lamelin JP et al. (1973) Human smooth muscle autoantibody. Its identification as antiactin antibody and a study of its binding to "nonmuscular" cells. Am J Pathol. 72(3):473-88.
[2] Gown AM, Vogel AM, Gordon D et al. (1985) A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes. J Cell Biol. 100(3):807- 13.
[3] Vandekerckhove J and Weber K (1981) Actin typing on total cellular extracts: a highly sensitive proteinchemical procedure able to distinguish different actins. Eur J Biochem. 113(3):595-603.
[4] Yuan SM (2015) _-Smooth Muscle Actin and ACTA2 Gene Expressions in Vasculopathies. Braz J Cardiovasc Surg. 30(6):644-9.
[5] Johnson GD, Holborow EJ and Glynn LE (1965) Antibody to smooth muscle in patients with liver disease. Lancet 2:878-879.

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