p40

Rb, 0.5 ml Conc.

Artikelnummer:1-P4001-05
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human p40
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Nuclear
Kontrolle:Lung, lung squamous cell carcinoma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

p40 antibody recognizes the shortest variant of human p53, and it may be a valuable marker in cases where p63 has traditionally been used. The transcription factor p63 has been identified as a p53 homologue. At present, p63 is the most frequently used marker for lung squamous cell carcinoma (SqCC). In a recent study, p40 staining was equivalent to p63 in sensitivity for SqCC, but was exhibited markedly superior specificity vs. p63. This report strongly supports the routine use of p40 as an alternative for p63 when used in the diagnosis of pulmonary squamous cell carcinoma. p40 may prove to be an important antibody in the differential diagnosis of lung adenocarcinoma vs. lung SqCC.

Literatur

[1] Bishop JA, Teruya-Feldstein J, Westra WH et al. (2012): p40 (_Np63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol. 25(3):405-15.
[2] Nobre AR, Albergaria A and Schmitt F (2013): p40: a p63 isoform useful for lung cancer diagnosis - a review of the physiological and pathological role of p63. Acta Cytol. 57(1):1-8.
[3] Ao MH, Zhang H1, Sakowski L et al. (2014): The utility of a novel triple marker (combination of TTF1, napsin A, and p40) in the subclassification of non-small cell lung cancer. Hum Pathol. 45(5):926-34.
[4] Parsons CLM, Tucker HLM, Akers RM and Daniels KM (2018): Technical note: p40 antibody as a replacement for p63 antibody in bovine mammary immunohistochemistry. J Dairy Sci.101(8):7614-7617.
[5] Reddy AB, Chatterjee A, Rothblum L et al. (1989): Isolation and characterization of complementary DNA to proliferating cell nucleolar antigen P40. Cancer Res. 49(7):1763-7.
[6] Hagiwara K, McMenamin MG, Miura K and Harris CC (1999): Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers. Cancer Res. 59(17):4165-9.

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