Uroplakin III

Rb, 6 ml RTU

Artikelnummer:2-UR015-12
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Uroplakin III
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Membranous, cytoplasmic
Kontrolle:Urothelial carcinoma, bladder
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Uroplakin III is a 47 kD glycoprotein of the asymmetrical unit. Uroplakin III is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. It stains the urothelial surface membrane of human renal pelvis, ureter, bladder, and urethra. Studies have also shown Uroplakin III expression was restricted to a subset of p63-negative carcinoma cells, including anaplastic carcinoma cells.

Literatur

[1] Kaufmann O, Volmerig J and Dietel M (2000): Uroplakin III is a highly specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Am J Clin Pathol. 113(5):683-7.
[2] Yuasa T, Yoshiki T, Tanaka T et al. (1998): Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma. Jpn J Cancer Res. 89(9):879-82.
[3] Wu XR, Manabe M, Yu J and Sun TT (1990): Large scale purification and immunolocalization of bovine uroplakins I, II, and III. Molecular markers of urothelial differentiation. J Biol Chem. 265(31):19170-9.
[4] Wu XR and Sun TT (1993): Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein. J Cell Sci. 106 ( Pt 1):31-43.

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