PAX8

Rb, 0.5 ml Conc.

Artikelnummer:1-PA079-05
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Concentrate
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human PAX8
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Nuclear
Kontrolle:Kidney, renal cell carcinoma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

PAX8 is a member of the paired box (PAX) family of transcription factors that encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. PAX8 is involved in thyroid follicular cell development and is expressed in thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas.

Literatur

[1] Bellevicine C, Iaccarino A, Malapelle U et al. (2013): PAX8 is expressed in anaplastic thyroid carcinoma diagnosed by fine-needle aspiration: a study of three cases with histological correlates. Eur J Endocrinol. 169(3):307-11.
[2] Ozcan A, Shen SS, Hamilton C et al. (2011): PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study. Mod Pathol. 24(6):751-64.
[3] Tong GX, Yu WM, Beaubier NT et al. (2009): Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Mod Pathol. 22(9):1218-27.
[4] Plachov D, Chowdhury K, Walther C et al. (1990): Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development. 110(2):643-51.
[5] Poleev A, Fickenscher H, Mundlos S et al. (1992): PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. Development. 116(3):611-23.
[6] Wang Y, Wang Y, Li J et al. (2031): PAX8: a sensitive and specific marker to identify cancer cells of ovarian origin for patients prior to neoadjuvant chemotherapy. J Hematol Oncol. 6:60.

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