Her2/Neu

Rb, 6 ml RTU

Artikelnummer:2-HE112-12
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic C-terminal peptide of human HER2/ErbB2 protein.
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Membranous
Kontrolle:Breast Carcinoma
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Human Epidermal Growth Factor Receptor 2 belongs to the family of transmembrane receptor-like tyrosine kinases. In certain aggressive types of breast cancer this receptor is overexpressed. In case of overexpression the receptor is activated without ligand.

Literatur

[1] MŽnard S, Pupa SM, Campiglio M and Tagliabue E (2003): Biologic and therapeutic role of HER2 in cancer. Oncogene. 22: 6570-6578.
[2] Ellis CM, Dyson MJ, Stephenson TJ and Matlby EL (2005): HER2 amplification status in breast cancer: a comparison between immunohistochemical staining and fluorescence in situ hybridisation using manual and automated quantitative image analysis scoring techniques. J Clin Pathol. 58: 710-714.
[3] Muthuswamy SK, Gilman M and Brugge JS (1999): Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Mol Cell Biol. 19(10): 6845-6857.
[4] Klapper LN, Waterman H, Sela M and Yarden Y (2000): Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2. Cancer Res. 60(13): 3384-3388.
[5] Ricardo SA, Milanezi F, Carvalho ST et al. (2007): HER2 evaluation using the novel rabbit monoclonal antibody SP3 and CISH in tissue microarrays of invasive breast carcinomas. J Clin Pathol. 60(9):1001-5.
[6] Hudziak RM, Schlessinger J and Ullrich A (1987): Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc Natl Acad Sci U S A. 84(20):7159-63.
[7] Kokai Y, Cohen JA, Drebin JA and Greene MI (1987): Stage- and tissue-specific expression of the neu oncogene in rat development. Proc Natl Acad Sci U S A. 84(23):8498-501.

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