Cytokeratin 20

Ks20.8, Ms, 6 ml RTU

Artikelnummer:2-CY246-12
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Ks20.8
Spezies:Mouse
Ig Unterklasse:IgG2a/k
Immunogen:Cytokeratin 20
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Cytoplasmic
Kontrolle:Bladder, colon carcinoma, colon mucosa
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Cytokeratin 20 is a type I keratin that is a part of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. This antibody is useful in the differentiation of specific types of simple epithelial cells of the urinary tract as well as normal and malignantly transformed epithelia. It detects adenocarcinomas of the colon, stomach, pancreas and biliary system, mucinous ovarian tumors, transitional-cell and Merkel cell carcinomas.

Literatur

[1] Kummar S, Fogarasi M, Canova A et al. (2002): Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma. Br J Cancer. 86(12):1884-7.
[2] Chu P, Wu E and Weiss LM (2000): Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol. 13(9):962-72.
[3] Moll R, Löwe A, Laufer J and Franke WW (1992): Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol. 140(2):427-47.
[4] Moll R, Schiller DL and Franke WW (1990): Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. J Cell Biol. 111(2):567-80.
[5] Wauters CC, Smedts F, Gerrits LG et al. (1995): Keratins 7 and 20 as diagnostic markers of carcinomas metastatic to the ovary. Hum Pathol. 26(8):852-5.

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