Androgen receptor

Rb, 0.5 ml Conc.

Artikelnummer:1-AN011-05
Menge:
Technische Daten
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Kontrolle:Prostate
Zelluläre Lokalisation:Nuclear
Fixierung:1) NOTOXhisto 2) Formalin
Anwendung AK:IHC(p),IHC(f)
Immunogen:Synthetic peptide of human Androgen Receptor protein N-terminal
Ig Unterklasse:IgG
Spezies:Rabbit
Klon:Polyclonal
Format AK:Concentrate
Reaktivität AK:Human, others not tested.
Synonyme:AIS, AIS, ANDR_HUMAN, Androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease), Androgen receptor, AR, DHTR, Dihydro Testosterone Receptor, Dihydrotestosterone receptor, HUMARA, HYSP1, HYSP1, KD, NR3C4, Nuclear receptor subfamily 3 group C member 4, SBMA, SMAX1, Spinal and bulbar muscular atrophy, TFM.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Androgen receptor is a nuclear receptor/DNA-binding transcription factor that regulates gene expression. This antibody recognizes epithelial and stromal cells in prostate as well as epithelial cells in breast and hepatocyte. AR is essential for growth of prostate cancer cells and therefore useful in evaluating prostate cancer.

Literatur

[1] Guo Z, Dai B, Jiang T et al. (2006) Regulation of androgen receptor activity by tyrosine phosphorylation Cancer Cell 10(4):309-19.
[2] Callewaert L, Verrijdt G, Christiaens V et al. (2003) Dual function of an amino-terminal amphipatic helix in androgen receptor-mediated transactivation through specific and nonspecific response elements. J Biol Chem 278(10):8212-8.
[3] Gao L and Alumkal J (2010) Epigenetic regulation of androgen receptor signaling in prostate cancer. Epigenetics 5(2):100-4.

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