Androgen receptor

Rb, 6 ml RTU

Artikelnummer:2-AN011-12
Menge:
Technische Daten
Reaktivität AK:Human, others not tested.
Format AK:Ready-to-use
Klon:Polyclonal
Spezies:Rabbit
Ig Unterklasse:IgG
Immunogen:Synthetic peptide of human Androgen Receptor protein N-terminal
Anwendung AK:IHC(p),IHC(f)
Fixierung:1) NOTOXhisto 2) Formalin
Zelluläre Lokalisation:Nuclear
Kontrolle:Prostate
Lagerung AK:Store at 2 - 8 °C. Do not use after expiration date indicated on the vial.
Verfügbar in folgenden Ländern:world wide (except US)
Status:IVD
Beschreibung

Androgen receptor is a nuclear receptor/DNA-binding transcription factor that regulates gene expression. This antibody recognizes epithelial and stromal cells in prostate as well as epithelial cells in breast and hepatocyte. AR is essential for growth of prostate cancer cells and therefore useful in evaluating prostate cancer.

Literatur

[1] Guo Z, Dai B, Jiang T et al. (2006) Regulation of androgen receptor activity by tyrosine phosphorylation Cancer Cell 10(4):309-19.
[2] Callewaert L, Verrijdt G, Christiaens V et al. (2003) Dual function of an amino-terminal amphipatic helix in androgen receptor-mediated transactivation through specific and nonspecific response elements. J Biol Chem 278(10):8212-8.
[3] Gao L and Alumkal J (2010) Epigenetic regulation of androgen receptor signaling in prostate cancer. Epigenetics 5(2):100-4.

Kontakt